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FLASH GENE
Symbol SLC18A2 contributors: mct - updated : 01-02-2011
HGNC name solute carrier family 18 (vesicular monoamine), member 2
HGNC id 10935
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in platelets from patients with Parkinson disease
constitutional     --over  
might be a compensatory mechanism to restore and maintain synaptic transmission in dopaminergic midbrain neurons during nicotine withdrawal
tumoral     --low  
silencing by DNA hypermethylation and/or allelic loss is a frequent event in prostate cancer and a novel independent predictor of biochemical recurrence after prostatectomy
Susceptibility
  • to alcoholism
  • to Parkinson disease
  • to schizophrenia and bipolar disorder
  • Variant & Polymorphism SNP
  • 14234G>A and 2504T>C decreasing the risk of alcoholism
  • protective role for gain-of -function haplotypes in sporadic Parkinson disease, through increasing of sequestration of dopamine in secretory vesicles
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS