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FLASH GENE
Symbol LETM1 contributors: mct - updated : 09-05-2014
HGNC name leucine zipper-EF-hand containing transmembrane protein 1
HGNC id 6556
ASSOCIATED DISORDERS
corresponding disease(s) WHS , WHSCR
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
in most patients with the Wolf-Hirschhorn syndrome exhibiting seizures and putative contributor to the phenotype, but preserved in those without seizures
tumoral     --over  
significantly increased in multiple human cancer tissues compared with normals
Susceptibility
Variant & Polymorphism
Candidate gene for seizures in Wolf-Hirschhorn syndrome
Marker
Therapy target
SystemTypeDisorderPubmed
cancerlung 
adenovirus-mediated LETM1 may provide a useful target for designing lung tumor prevention and treatment
ANIMAL & CELL MODELS