Symbol
| ID3
| contributors: mct - updated : 03-06-2019
|
HGNC name
| inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
|
HGNC id
| 5362
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --low
|  
|
neuroblastoma, ovarian adenocarcinoma | tumoral
|  
|  
| --over
|  
|
in Burkitt lymphoma | constitutional
|  
|  
| --other
|  
|
aberrant expressions of endometrial ID3 and CTLA4 are associated with unexplained repeated implantation failure and recurrent miscarriage | tumoral
|  
|  
| --over
|  
|
was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas | |
Susceptibility
|
to carotid intima-media thickness to coronary artery pathology |
Variant & Polymorphism
SNP
| common SNP in the ID3 gene linked to loss of ID3 function and increased carotid intima-media thickness |
|
association of ID3 SNP rs11574 directly with human coronary artery pathology |
|
|
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | reproductive | breast | |
peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi |
| | | |
| combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice |