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FLASH GENE
Symbol ID3 contributors: mct - updated : 03-06-2019
HGNC name inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
HGNC id 5362
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
neuroblastoma, ovarian adenocarcinoma
tumoral     --over  
in Burkitt lymphoma
constitutional     --other  
aberrant expressions of endometrial ID3 and CTLA4 are associated with unexplained repeated implantation failure and recurrent miscarriage
tumoral     --over  
was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas
Susceptibility
  • to carotid intima-media thickness
  • to coronary artery pathology
  • Variant & Polymorphism SNP
  • common SNP in the ID3 gene linked to loss of ID3 function and increased carotid intima-media thickness
  • association of ID3 SNP rs11574 directly with human coronary artery pathology
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    peptide aptamer, Id1/3-PA7, specifically interacting with ID1 and ID3, could represent a nontoxic exogenous agent that can significantly provoke antiproliferative and apoptotic effects in breast cancer cells, which are associated with deregulated expressi
    ANIMAL & CELL MODELS
  • combined Id1 and Id3 deletion leads to dysregulation of the hematopoietic transcriptional network and multiple defects in erythropoietic development in adult mice