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FLASH GENE
Symbol MELK contributors: mct/pgu - updated : 28-04-2020
HGNC name maternal embryonic leucine zipper kinase
HGNC id 16870
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
dysregulated expression of FAU and MELK is associated with poor prognosis in breast cancer
tumoral     --over  
correlated with poor overall survival (OS) and disease-free survival (DFS) of Pancreatic cancer patients
tumoral     --over  
in TNBCs (Triple-negative breast cancer) as compared with ER-positive breast cancers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • attractive target for improvements in breast cancer risk prediction and prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    considered as a potential therapeutic target for cancers
    cancerreproductivebreast
    attractive targets for improvements in breast cancer therapy
    cancerdigestiveoesophagus
    is a potential therapeutic target for ESCC patients, even those in an advanced stage
    cancerhead and neck 
    MELK inhibition may also be promising for clinical applications in the treatment of HNSCC
    cancerbrainglioma/neuroblstoma
    is a novel therapeutic target for NB and its inhibitor OTSSP167 is a promising drug for further clinical development
    cancer  
    MELK inhibition may be effective for human cancers even if TP53 is mutated
    immunologyinfectious 
    potential target for anti-HIV therapy
    cancerdigestiveliver
    promising molecular target to develop therapeutic strategies for patients with advanced HCC
    ANIMAL & CELL MODELS