Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SPINT2 contributors: mct - updated : 15-12-2016
HGNC name serine peptidase inhibitor, Kunitz type, 2
HGNC id 11247
ASSOCIATED DISORDERS
corresponding disease(s) CSODS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in pancreatic cancer
tumoral     --low  
frequently hypermethylated and underexpressed in HCC
tumoral     --low  
in ovarian and cervical cancers
tumoral        
silenced by promoter hypermethylation in pediatric medulloblastoma
tumoral     --low  
hypermethylated in RCC
tumoral     --low  
in myelodysplastic syndromes and modulates cell-cell adhesion
constitutional     --over  
of SPINT1 and SPINT2 in the liver in cholangiopathies with ductular reactions which are possibly involved in liver fibrosis and hepatic differentiation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveovary
could be considered a therapeutic target for treatment approches in ovarian and cervical cancers
cancerreproductivebreast
SPINT2 expression in breast cancer correlates with tumor aggressiveness
cancerreproductivebreast
low level of SPINT2 in the breast cancer tissues is associated with an overall poor outlook
cancerreproductiveuterus
could be considered as therapeutic targets and used as favorable prognosis markers for endometrial cancer
ANIMAL & CELL MODELS
  • reduced Prss8 activity restores placental differentiation, embryonic survival, and neural tube closure in Spint2–deficient mice