Symbol
| STIP1
| contributors: mct - updated : 08-03-2019
|
HGNC name
| stress-induced-phosphoprotein 1
|
HGNC id
| 11387
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| translocation
|  
| protein chimeric
|
chimeric protein gamma-heregulin (5'-STIP1-NRG1-3') resulting from the translocation t(8;11) (p12;q13) and the fusion with neuregulin | tumoral
|  
|  
| --over
|  
|
in hepatocellular carcinoma and associated with poor clinical prognosis | constitutional
|  
|  
| --low
|  
|
reduced STIP1 levels can contribute to phenotypes related to ASD | |
Susceptibility
|
to variations in corticosteroid response in asthmatic subjects with reduced lung function |
Variant & Polymorphism
other
| genetic variations might play a role in regulating corticosteroid response in asthmatic subjects with reduced lung function |
|
|
Candidate gene
| ideal candidate gene for glaucoma |
Marker
| STIP1 expression might be used as a prognostic biomarker for cancer treatment |
|
is a secreted biomarker for human ovarian cancer and promotes cancer cell proliferation |
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | digestive | liver | |
STIP1 might be a therapeutic target in hepatocellular carcinoma |
| |