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FLASH GENE
Symbol STIP1 contributors: mct - updated : 08-03-2019
HGNC name stress-induced-phosphoprotein 1
HGNC id 11387
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation   protein chimeric
chimeric protein gamma-heregulin (5'-STIP1-NRG1-3') resulting from the translocation t(8;11) (p12;q13) and the fusion with neuregulin
tumoral     --over  
in hepatocellular carcinoma and associated with poor clinical prognosis
constitutional     --low  
reduced STIP1 levels can contribute to phenotypes related to ASD
Susceptibility to variations in corticosteroid response in asthmatic subjects with reduced lung function
Variant & Polymorphism other
  • genetic variations might play a role in regulating corticosteroid response in asthmatic subjects with reduced lung function
  • Candidate gene ideal candidate gene for glaucoma
    Marker
  • STIP1 expression might be used as a prognostic biomarker for cancer treatment
  • is a secreted biomarker for human ovarian cancer and promotes cancer cell proliferation
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    STIP1 might be a therapeutic target in hepatocellular carcinoma
    ANIMAL & CELL MODELS