Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GJC1 contributors: mct - updated : 29-05-2019
HGNC name gap junction protein, gamma 1, 45kDa
HGNC id 4280
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
reduced in colorectal carcinomas compared to normal tissue samples, and DNA hypermethylation of the promoter region of GJC1, encoding GJC1, is an important mechanism in silencing gene expression in colorectal cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
could be a potential target for preventing liver cancer in patients with diabetes (PMID: 3007821)
ANIMAL & CELL MODELS
  • Cx45-deficient embryos that exhibit dysregulated transforming growth factor-beta and lack mural cell development