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FLASH GENE
Symbol SLIT2 contributors: mct/ - updated : 24-03-2014
HGNC name slit homolog 2 (Drosophila)
HGNC id 11086
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
by hypermethylation in various cancers, including breast and lung cancer, colorectal carcinoma, and gliomas
tumoral     --other  
epigenetic silencing of in hepatocellular carcinoma (decrease of SLIT2 expression was also associated with lymph node metastasis)
tumoral       loss of function
in human cancers and may regulate apoptosis and metastasis
tumoral     --low  
by epigenetic mechanisms, in a majority of metastatic prostate tumors, showing a negative correlation with EZH2
tumoral     --low  
in pancreatric carcinoma exhibited a higher incidence and a higher fraction of tumor-infiltrated lymph nodes
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • potential biomarker for aggressive solid tumors
  • may be a potent noninvasive prognostic biomarker of prostate cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    useful as a therapeutic target in the treatment of hepatocellular carcinoma
    ANIMAL & CELL MODELS
  • mice lacking Slit2 or Robo3 have a reduced number of GnRH neurons in the forebrain, but a normal complement of their supporting axons, pointing to a direct role for these molecules in GnRH neuron migration