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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

NEK2

contributors: mct/ - updated : 22-01-2016

HGNC name	NIMA (never in mitosis gene a)-related kinase 2
HGNC id	7745

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

RP67

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         aberrant regulation of Nek2 activity can lead to aneuploid defects characteristic of cancer cells tumoral     --over   in all breast carcinoma cell lines constitutional     --over   may promote aneuploidy by disrupting the control of the mitotic checkpoint

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel potential biomarker for diagnosis of breast cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive breast useful therapeutic molecular target for the treatment of breast carcinoma both in ER-positive and ER-negative cases cancer     inhibition mechanism of NEK2 kinase may contribute to the development of a novel type of anti-cancer drugs cancer reproductive breast possible therapeutic target for human breast cancer especially for breast ductal carcinoma in situ

ANIMAL & CELL MODELS