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FLASH GENE
Symbol NEK2 contributors: mct/ - updated : 22-01-2016
HGNC name NIMA (never in mitosis gene a)-related kinase 2
HGNC id 7745
ASSOCIATED DISORDERS
corresponding disease(s) RP67
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
aberrant regulation of Nek2 activity can lead to aneuploid defects characteristic of cancer cells
tumoral     --over  
in all breast carcinoma cell lines
constitutional     --over  
may promote aneuploidy by disrupting the control of the mitotic checkpoint
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • novel potential biomarker for diagnosis of breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    useful therapeutic molecular target for the treatment of breast carcinoma both in ER-positive and ER-negative cases
    cancer  
    inhibition mechanism of NEK2 kinase may contribute to the development of a novel type of anti-cancer drugs
    cancerreproductivebreast
    possible therapeutic target for human breast cancer especially for breast ductal carcinoma in situ
    ANIMAL & CELL MODELS