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FLASH GENE
Symbol PDE9A contributors: mct - updated : 18/10/2008
HGNC name phosphodiesterase 9A
HGNC id 8795
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
significantly higher in the reticulocytes and neutrophils of sickle cell disease individuals, compared to control cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target since elevation of haematopoietic intracellular cGMP may be beneficial in SCD (sickle cell disease), the relatively limited tissue distribution of PDE9A suggests that it could represent a novel drug target for SCD
ANIMAL & CELL MODELS