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FLASH GENE
Symbol NLGN1 contributors: mct/pgu - updated : 30-12-2020
HGNC name neuroligin 1
HGNC id 14291
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation     loss of function
in Alzheimer disease, and in hippocampal neurons, the p.Thr271fs mutation abolishes the ability of NLGN1 to promote the formation of glutamatergic synapses
Susceptibility to autism spectrum disorder (ASD)
Variant & Polymorphism other
  • NLGN1 Pro89Leu (P89L) missense variant associated with ASD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS