Symbol
| CNTF
| contributors: mct/shn - updated : 23-10-2018
|
HGNC name
| ciliary neurotrophic factor
|
HGNC id
| 2169
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
in brain in the lateral corticospinal tract in SLA (modifier gene leading to early onset of ALS1 in patients with SOD1 mutation) | constitutional
|  
|  
| --low
|  
|
decrease was found in preeclampsia as compared with normal pregnancy (circulating CNTF might be associated with physiological and abnormal insulin resistance during pregnancy) | |
Susceptibility
|
to higher body mass index in males in Europa, not in American people |
Variant & Polymorphism
other
|
| |
Candidate gene
| role in therapeutic strategy to alleviate obesity-associated diseases |
|
therapeutic potential of CNTF for the clinical treatment of progressive neurodegenerative diseases involving glutamate overflow |
Marker
Therapy target
| | |
| CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration |