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FLASH GENE
Symbol CNTF contributors: mct/shn - updated : 23-10-2018
HGNC name ciliary neurotrophic factor
HGNC id 2169
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in brain in the lateral corticospinal tract in SLA (modifier gene leading to early onset of ALS1 in patients with SOD1 mutation)
constitutional     --low  
decrease was found in preeclampsia as compared with normal pregnancy (circulating CNTF might be associated with physiological and abnormal insulin resistance during pregnancy)
Susceptibility to higher body mass index in males in Europa, not in American people
Variant & Polymorphism other
Candidate gene
  • role in therapeutic strategy to alleviate obesity-associated diseases
  • therapeutic potential of CNTF for the clinical treatment of progressive neurodegenerative diseases involving glutamate overflow
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration