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FLASH GENE
Symbol RCE1 contributors: mct/npt/pgu - updated : 08-07-2009
HGNC name RCE1 homolog, prenyl protein protease (S. cerevisiae)
HGNC id 13721
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
peptidomimetic inhibitors of RCE1 may be useful in treatment of cancer
immunologyinflammatory 
peptidomimetic inhibitors of RCE1 may be useful in treatment of inflammatory disease
ANIMAL & CELL MODELS
hearts from heart-specific Rce1 knockout mice manifested reduced levels of both the Rce1 mRNA and CAAX endoprotease activity, and the hearts manifested an accumulation of CAAX protein substrates; heart-specific Rce1 knockout mice had a dilated cardiomyopathy