Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCL26 contributors: mct - updated : 03-06-2020
HGNC name chemokine (C-C motif) ligand 26
HGNC id 10625
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
is associated with fibrotic progression of primary biliary cholangitis
constitutional       gain of function
of CCL26 in bullous pemphigoid (BP) is linked to the lesional accumulation of activated eosinophils in the skin
constitutional     --over  
serum CCL11, CCL24 and CCL26 are upregulated in primary biliary cholangitis but CCL11 and CCL26 are associated with fibrotic progression
Susceptibility to asthma and total IgE dosage
Variant & Polymorphism SNP 77C > T, +716A > G, EOT 3 +1579G > A increasing the risk of asthma
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
allergy  
CCR3 and CCR5 receptor/ligand signaling pathways may be important targets for development of novel mechanism-based adjunctive therapies designed to abrogate the chronic inflammation associated with airway diseases
allergyasthm 
potential target for treating patients with eosinophilic asthma that are refractory to classic therapies
ANIMAL & CELL MODELS