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FLASH GENE
Symbol SNCAIP contributors: mct - updated : 02-10-2013
HGNC name synuclein, alpha interacting protein (synphilin)
HGNC id 11139
ASSOCIATED DISORDERS
corresponding disease(s) PARK25
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
in Parkinson disease (component of Lewy bodies in brain)
constitutional     --over  
and accumulated in brain lesions in which SNCA is a major component
tumoral somatic mutation      
SNCAIP duplication is a somatic event highly specific to Group 4 medulloblastoma
Susceptibility
Variant & Polymorphism other R621C mutation increase the risk of Parkinson disease
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS