Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CD3E contributors: mct - updated : 01-09-2017
HGNC name CD3E antigen, epsilon polypeptide (TiT3 complex)
HGNC id 1674
ASSOCIATED DISORDERS
corresponding disease(s) IMD18 , SCIDTE
related resource CD3Ebase: Mutation registry for autosomal recessive CD3epsilon immunodeficiency
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in patients with aplastic anemia (AA)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • CD3epsilon transgenic mice, tgepsilon26, exhibits severe immunodeficiency associated with early arrest of T cell development
  • mice lacking a functional Cd3e-basic-rich stretch (BRS) exhibited substantial reductions in thymic cellularity and limited CD4- CD8- double-negative (DN) 3 to DN4 thymocyte transition