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FLASH GENE
Symbol CLOCK contributors: mct - updated : 19-12-2016
HGNC name clock homolog (mouse)
HGNC id 2082
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
of the clock component CLOCK of beta cells leads to hypoinsulinaemia and diabetes
Susceptibility
  • to sleep dysregulation in major depression disorder and bipolar disorder
  • to a more severe lifetime body weight loss in eating disorder
  • to adult attention-deficit hyperactivity disorder
  • to variation of energy intake and sleep pattern
  • Variant & Polymorphism other
  • 3111T/C predispose eating disorders patients to a more severe lifetime body weight loss
  • polymorphisms increasing the risk of adult attention-deficit hyperactivity disorder
  • association of genetic variation at CLOCK with total energy intake, which was particularly relevant for SNP rs3749474
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • cell structure and function of skeletal muscle is impaired in Clock delta 19 and Bmal1&
  • 8722;/&
    8722; mice
  • Clock-deficient mice showed increased synthesis of collagen, increased oxidative stress, and greater transforming growth factor-beta (TGFB1) expression