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FLASH GENE
Symbol BIRC5 contributors: mct - updated : 23-11-2015
HGNC name baculoviral IAP repeat-containing 5
HGNC id 593
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
disturbed expression of BIRC5 and EPR1 in hematological malignancy (in acute myeloid leukemia with unfavourable prognostic factor)
tumoral     --over  
with TERT in soft tissue sarcoma with very poor outlook, and in stomach tumor cell nuclei (with favorable prognosis)
constitutional     --over  
in endometriosis
tumoral     --over  
in uterus cancer,panceas, colon, gastric, breast, prostate adenocarcinomas, in alveolar rhabdomyosarcoma
tumoral       gain of function
in esophageal cancer
tumoral     --low  
silencing promotes XIAP degradation and enhances GZMM-induced caspase activation as well as GZMM- and NK cell-induced cytolysis of target tumor cells
tumoral     --over  
in the majority of non-small cell lung carcinoma, together with the abundant or upregulated expression of HBXIP and XIAP suggest that tumours are endowed with resistance against a variety of apoptosis-inducing conditions
tumoral     --over  
overexpression of FOXM1, XIAP, and BIRC5 contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
co-suppression of POU5F1 and BIRC5 is potentially beneficial for HCC treatment
cancer  
therapeutic use of Survivin-targeted RNA interference for tumours that express high levels of this molecule
cancerdigestiveoesophagus
promoter could be useful tools for developing esophageal cancer-specific gene therapy vectors
cardiovascularatheroma 
promising new target for myocardial regeneration
cancer  
potentially important interaction between BECN1 and BIRC5 having therapeutic implication in human tumor cells
ANIMAL & CELL MODELS
  • survivin gene deletion in the kidneys results in a cystic phenotype
  • Surv(-/-) mice exhibit severe global conduction attenuations in atrial and ventricular myocardium as well as the specific conduction system (22976005)