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FLASH GENE
Symbol ABCB5 contributors: mct - updated : 22-12-2021
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 5
HGNC id 46
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in melanomas
tumoral     --over  
significantly associated with tumour progression and recurrence of the oral squamous cell carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerskin 
potential therapeutic target for melanoma (PMID: 28821433)
cancerdigestivecolon
ABCB5 blockade might represent a strategy in Colorectal cancer therapy
ANIMAL & CELL MODELS
  • Abcb5 loss of function in Abcb5 knockout mice causes depletion of quiescent limbal stem cells (LSCs), due to enhanced proliferation and apoptosis, and results in defective corneal differentiation and wound healing