Symbol
| ABCB5
| contributors: mct - updated : 22-12-2021
|
HGNC name
| ATP-binding cassette, sub-family B (MDR/TAP), member 5
|
HGNC id
| 46
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in melanomas | tumoral
|  
|  
| --over
|  
|
significantly associated with tumour progression and recurrence of the oral squamous cell carcinoma  | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | skin | |  |
potential therapeutic target for melanoma (PMID: 28821433) | cancer | digestive | colon |  |
ABCB5 blockade might represent a strategy in Colorectal cancer therapy |
| | | |
| Abcb5 loss of function in Abcb5 knockout mice causes depletion of quiescent limbal stem cells (LSCs), due to enhanced proliferation and apoptosis, and results in defective corneal differentiation and wound healing  |