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FLASH GENE

Symbol

ABCB5

contributors: mct - updated : 22-12-2021

HGNC name	ATP-binding cassette, sub-family B (MDR/TAP), member 5
HGNC id	46

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in melanomas tumoral     --over   significantly associated with tumour progression and recurrence of the oral squamous cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   potential therapeutic target for melanoma (PMID: 28821433) cancer digestive colon ABCB5 blockade might represent a strategy in Colorectal cancer therapy

ANIMAL & CELL MODELS

Abcb5 loss of function in Abcb5 knockout mice causes depletion of quiescent limbal stem cells (LSCs), due to enhanced proliferation and apoptosis, and results in defective corneal differentiation and wound healing