Symbol
| DLGAP2
| contributors: mct/npt - updated : 04-05-2021
|
HGNC name
| discs, large (Drosophila) homolog-associated protein 2
|
HGNC id
| 2906
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
may contribute to the pathogenesis of schizophrenia | constitutional
|  
|  
| --low
|  
|
lower cortical DLGAP2 expression is observed in AD and is associated with more plaques and tangles at autopsy and faster cognitive decline | |
Susceptibility
|
to male age infertility to schizophrenia to late-onset Alzheimer disease |
Variant & Polymorphism
other
| age-related sperm differential methylation that accounted for 64 p100 of the effect of male age on lower fertilization rate |
|
variations in DLGAP2 associated with risk of late-onset Alzheimer's disease |
|
|
Candidate gene
Marker
Therapy target
| | | |
| Dlgap2 (-/-) mice displayed exacerbated aggressive behaviors in the resident-intruder task, and elevated social dominance in the tube test and exhibited a clear reduction of receptors and scaffold proteins in cortical synapses (PMID |