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FLASH GENE
Symbol DLGAP2 contributors: mct/npt - updated : 04-05-2021
HGNC name discs, large (Drosophila) homolog-associated protein 2
HGNC id 2906
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
may contribute to the pathogenesis of schizophrenia
constitutional     --low  
lower cortical DLGAP2 expression is observed in AD and is associated with more plaques and tangles at autopsy and faster cognitive decline
Susceptibility
  • to male age infertility
  • to schizophrenia
  • to late-onset Alzheimer disease
  • Variant & Polymorphism other
  • age-related sperm differential methylation that accounted for 64 p100 of the effect of male age on lower fertilization rate
  • variations in DLGAP2 associated with risk of late-onset Alzheimer's disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dlgap2 (-/-) mice displayed exacerbated aggressive behaviors in the resident-intruder task, and elevated social dominance in the tube test and exhibited a clear reduction of receptors and scaffold proteins in cortical synapses (PMID