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FLASH GENE
Symbol IL32 contributors: mct - updated : 26-03-2020
HGNC name interleukin 32
HGNC id 16830
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in rheumatoid arthritis synovial tissue
tumoral     --other  
dysregulation in myelodysplastic syndrome (MDS) and myeloproliferative disorder
tumoral     --other  
expressed in human melanoma
constitutional     --over  
in atherosclerotic plaques of coronary artery disease (CAD) patients when compared with normal coronary arteries
constitutional     --over  
significantly higher in patients with Behçet disease
Susceptibility
  • to rheumatoid arthritis
  • to Multiple sclerosis (MS)
  • to Systemic lupus erythematosus (SLE)
  • Variant & Polymorphism SNP
  • increase in serum levels of IL32 in accordance with additive effect of the presence of C allele in Multiple sclerosis (MS) patients
  • rs28372698 SNP was associated with the susceptibility to SLE
  • Candidate gene
    Marker
  • IL32 could play a role in predicting response to treatment in rheumatoid arthritis
  • IL32 may serve as a marker for diagnosis of osteosarcoma
  • IL32 expression might be valuable as a biomarker for cancer
  • is a molecular marker of latent tuberculosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    IL32 may increase TIMP3 expression via hypomethylation through inactivation of NFKB1 activity, and thereby reduce lung tumor growth
    digestiveliver 
    could be considered as a therapeutic target in patients with NFALD
    cancerhemopathy 
    therapeutic targets for patients with myelodysplastic syndrome (MDS) and myeloproliferative disorder
    cancerendocrinethyroid
    modulation of IL-32 alternative splicing could represent a novel strategy for the treatment of malignancies, in particular thyroid cancer
    immunologyinflammatory 
    may be a novel therapeutic target for airway inflammatory disease
    cancerbone 
    may serve for the treatment of osteosarcoma
    ANIMAL & CELL MODELS