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FLASH GENE
Symbol ADGRG1 contributors: mct - updated : 21-09-2016
HGNC name adhesion G protein-coupled receptor G1
HGNC id 4512
ASSOCIATED DISORDERS
corresponding disease(s) BFPP
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in gliomas, in glioblastoma multiforme tumors and esophageal squamous cell carcinomas
constitutional     --low  
in neural progenitor cells
tumoral        
expression of GPR56 protein is suppressed in human pancreatic cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene can be used as an neural stem cell (NSC) or neural progenitor cell (NPC) marker within the neural cell lineage, especially in combination with nestin
Marker
Therapy target
SystemTypeDisorderPubmed
cancerskin 
components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma
ANIMAL & CELL MODELS
  • loss of the mouse Gpr56 gene leads to neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation