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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ADGRG1

contributors: mct - updated : 21-09-2016

HGNC name	adhesion G protein-coupled receptor G1
HGNC id	4512

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BFPP

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gliomas, in glioblastoma multiforme tumors and esophageal squamous cell carcinomas constitutional     --low   in neural progenitor cells tumoral         expression of GPR56 protein is suppressed in human pancreatic cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene	can be used as an neural stem cell (NSC) or neural progenitor cell (NPC) marker within the neural cell lineage, especially in combination with nestin
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma

ANIMAL & CELL MODELS

loss of the mouse Gpr56 gene leads to neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation