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FLASH GENE
Symbol MBD2 contributors: mct/npt - updated : 03-07-2015
HGNC name methyl-CpG binding domain protein 2
HGNC id 6917
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
at the early stage of colorectal and stomach carcinogenesis
tumoral somatic mutation      
in colon and lung cancer
constitutional       gain of function
at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis (Wawrzik 2009)
constitutional     --low  
decreased expression of MBD2 and MBD4 might involve in the pathogenesis of primary immune thrombocytopenia
constitutional     --over  
of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS