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Symbol IRS2 contributors: mct/npt/pgu - updated : 12-06-2015
HGNC name insulin receptor substrate 2
HGNC id 6126
corresponding disease(s) NIDDM3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in macrophages enhanced their accumulation in the vascular wall accompanied by increased expression of proinflammatory mediators in macrophages
constitutional     --over  
in the kidney tubules of diabetic nephropathy
constitutional     --low  
in Type 2 diabetics as well as in Alzheimer patients (
  • polycystic ovary syndrome in non diabetic African-American women with th G/G genotype (G1057D) polymorphism
  • morbid obesity with glucose intolerance
  • Variant & Polymorphism
    Candidate gene
  • marker and/or mediator of diabetic nephropathy progression
  • Therapy target
    new models to develop inhibitors against IRSs for anticancer therapy
    neurologyneurodegenerativehuntington chorea
    decreasing IRS2 signaling could be part of a therapeutic approach to slow the progression of HD
    diabetemetabolic syndrom 
    reduced IRS2-mediated insulin signal in macrophages is a potentially important therapeutic target to prevent the progression of atherosclerosis in patients with type 2 diabetes
  • irs2-/- mice
  • chico-/-drosophila
  • chronic hyperinsulinemia downregulates the mRNA for IRS2 in ob/ob mice
  • female infertility caused by deletion of IRS2
  • less Irs2 signaling in aging brains can promote healthy metabolism, attenuate meal-induced oxidative stress, and extend the life span of overweight and insulin-resistant mice
  • Irs2-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function
  • liver content of GCK was reduced in Irs2(-/-) mice as compared with controls, although GCKR levels were similar
  • Irs2 (-/-) mice also exhibited reduced testicular size, suggesting that impairments in this model occur during development
  • complete disruption of Irs2 in mice impairs long-term potentiation (LTP) of synaptic transmission in the hippocampus