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FLASH GENE
Symbol BMP15 contributors: mct/npt - updated : 02-04-2021
HGNC name bone morphogenetic protein 15
HGNC id 1068
ASSOCIATED DISORDERS
corresponding disease(s) ODG2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
associated with primary ovarian insufficiency cause a defective production of bioactive protein (Rossetti 2009)
constitutional germinal mutation      
in BMP15 associated with Primary Ovarian Insufficiencyreduce mature protein production, activity, or synergy with GDF9
Susceptibility to premature ovarian failure (POF)
Variant & Polymorphism other mutations minor cause of ovarian insufficiency and POF
Candidate gene
Marker
  • GDF9 and BMP15 mRNAs in cumulus granulosa cells may be considered as new molecular markers for predicting oocyte developmental potential
  • Therapy target
    ANIMAL & CELL MODELS