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FLASH GENE
Symbol LMO7 contributors: mct - updated : 08-01-2020
HGNC name LIM domain only 7
HGNC id 6646
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of SRF target genes that regulate muscle and actin cytoskeleton functions
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina
  • Lmo7-null mice had growth retardation, decreased fiber size, and impaired skeletal muscle and cardiac function, and loss of Lmo7 in mice causes myopathic phenotypes similar to those seen in other EDMD mouse models