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FLASH GENE
Symbol CLDN1 contributors: SGE/shn - updated : 30-06-2015
HGNC name claudin 1
HGNC id 2032
ASSOCIATED DISORDERS
corresponding disease(s) ILVASC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer cells
tumoral     --over  
may be involved at early stages of transformation in inflammatory bowel disease -associated neoplasia
tumoral     --over  
in colorectal cancer
tumoral     --low  
correlated with the recurrence status and poor prognosis in esophageal cancer and its expression may be a good indicator of recurrence in esophageal cancer
tumoral     --low  
progressively decreased in solar keratosis and skin squamous cell carcinomas compared to normal skin
tumoral     --over  
of CLDN1 and CLDN10 indicates a favorable prognosis for overall survival in some patients with lung adenocarcinoma
Susceptibility
  • increased expression of claudin-1 in human primary colon carcinoma and metastasis and in cell lines derived from primary and metastatic tumors
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential markers and therapy target in colorectal cancer
    cancerdigestiveliver
    might provide a pivotal point for therapeutic intervention in hepatocellular carcinoma
    ANIMAL & CELL MODELS
    Cldn1(-/-) mice died within 1 d of birth with wrinkled skin with severely affected epidermal barrier