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FLASH GENE
Symbol TFR2 contributors: mct/pgu - updated : 22-10-2011
HGNC name transferrin receptor 2
HGNC id 11762
ASSOCIATED DISORDERS
corresponding disease(s) HFE3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
aberrantly expressed in colon cancer, preferentially associated with mucinous tumors
Susceptibility to serum levels of iron variation
Variant & Polymorphism other association of a common variant in the type-2 transferrin receptor (TFR2) gene with iron levels
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • iron overload due to deletion of Tfr2 in mice is more severe than that due to Hfe, and loss of both molecules results in pronounced iron overload