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FLASH GENE
Symbol DDX5 contributors: mct - updated : 19-10-2015
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
HGNC id 2746
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
increased expression and polyubiquitylated in colorectal tumors, may contribute to colon cancer formation by directly upregulating proto-oncogenes
tumoral     --over  
overexpressed in prostate cancer with a possible role in progression to hormone refractory disease
tumoral fusion      
gene fused in frame with ETV4 in prostate cancer, leading to the expression of a DDX5-ETV4 fusion protein
Susceptibility
Variant & Polymorphism SNP
  • SNP S480A is linked to a reduced repressive function of DDX5 and thus an enhanced fibrogenic activity
  • DDX5 minor allele is associated with increased risk of developing advanced fibrosis in patients with chronic hepatitis C
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential new target for modulating the Notch signaling in leukemia
    ANIMAL & CELL MODELS