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FLASH GENE
Symbol TNFRSF11B contributors: mct/npt/shn - updated : 19-09-2015
HGNC name tumor necrosis factor receptor superfamily, member 11b
HGNC id 11909
ASSOCIATED DISORDERS
corresponding disease(s) PDB7
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in hormone- resistant prostate tumor with good prognosis
constitutional germinal mutation      
associated with bone mineral density at different skeletal sites in adult men, but not in women
constitutional     --over  
in cirrhotic chronic liver disease, which could modulate bone loss
constitutional     --over  
by dendritic cells, increases with maturation and is NF-kappaB-dependent, possibly regulating immune responses in lymphoid tissues
Susceptibility
  • to osteoporotic fracture (to hip fractures)
  • to the progression of atherosclerosis and cardiovascular disease
  • to periodontitis
  • to coronary artery disease
  • to sporadic Paget bone disease
  • Variant & Polymorphism SNP , other
  • A163-G and T245-G were significantly more common among patients with vertebral fractures
  • 950 TC/1181 GC and 950 CC/1181 CC associated to an increased risk of coronary artery disease
  • TG haplotype of T950C and G1181C polymorphisms in the OPG gene may be useful genetic markers for the prediction of periodontitis (Park 2008)
  • G1181 allele, encoding lysine at codon 3 predisposing to the development of sporadic Paget bone disease
  • Lys3Asn polymorphism increases susceptibility to hip fractures among older white women
  • Candidate gene
    Marker
  • expression of TNFRSF11A, TNFSF11 and TNFRSF11B may be used as diagnostic markers to identify patients at high risk for aggressive Prostate carcinoma 6)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    effective suppression of Prostate carcinoma cell migration by TNFRSF11B via the blockage of TNFSF11 activity represents a potential therapeutic strategy for interfering with prostate tumor metastasis and progression to bone
    ANIMAL & CELL MODELS
  • OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the skull, and a high incidence of fractures
  • OCIF/OPG knockout mice are viable and fertile but exhibit severe osteoporosis due to enhanced osteoclastogenesis, and marked bone loss accompanied by destruction of growth plate and lack of trabecular bone in their femurs