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FLASH GENE
Symbol TNFRSF10B contributors: mct - updated : 07-01-2011
HGNC name tumor necrosis factor receptor superfamily, member 10b
HGNC id 11905
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in primary glioblastoma multiforme
tumoral     --low  
in B-cell non-Hodgkin lymphoma (B-NHL)
tumoral somatic mutation      
in head and neck cancer,with a mutation also present in the germ line of an affected patient
tumoral       gain of function
in colon cancer
constitutional     --over  
in patients with nonalcoholic steatohepatitis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
digestiveliversteatosis
caspase inhibitors in steatohepatitis or other approaches to reduce TNFRSF10B activation hold promise to ameliorate hepatocyte lipoapoptosis in fatty liver disease
cancerbrainglioma/neuroblstoma
target for future TNFSF10 therapy of glioblastoma
cancer  
application of TNFSF10 or anti-TNFSFR10B mAb therapies to cancer patients
cancer  
TNFRSF10B-stimulated JNK activation and its consequent fluxes into the pro-autophagic signaling pathways contribute to the autophagic cell death in cancer cells
cancer  
cytotoxic agents capable of up-regulating the expression of TNFRSF10A and TNFRSF10B can sensitize cancer cells to TNFSF10 induced apoptosis
ANIMAL & CELL MODELS