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FLASH GENE
Symbol HPN contributors: mct - updated : 28-09-2016
HGNC name hepsin (transmembrane protease, serine 1)
HGNC id 5155
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in prostate cancer with poor prognosis
tumoral     --over  
in ovarian cancer
tumoral     --over  
is one of the most consistently overexpressed genes in patients with prostate cancer
tumoral     --over  
in breast cancer tissues, which is associated with tumor growth and progression
tumoral     --over  
could be an important indication for high risk of endometrial cancer
Susceptibility to prostate cancer
Variant & Polymorphism SNP
  • three SNPs (rs45512696, rs2305745, rs2305747) were significantly associated with the risk of prostate cancer
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    inhibition of hepsin expression might be of therapeutic significance
    ANIMAL & CELL MODELS
  • deletion of hepsin (hepsin(-/-)) in mice resulted in enlarged hepatocytes and narrowed liver sinusoids
  • hearing impairment present in Hpn-null mice is characterized by a combination of various structural, cellular, and molecular abnormalities that are likely to affect different cochlear processes