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FLASH GENE
Symbol HDAC3 contributors: mct/ - updated : 10-04-2017
HGNC name histone deacetylase 3
HGNC id 4854
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in squamous cell lung carcinomas
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
blood  
HDAC3 inhibitors are being considered as promising candidates for cancer therapy
blood  
promising target for therapies aiming to expand hematopoietic stem cells
neurologyneurodegenerative 
HDAC3 inhibitors being tested for relief of expansion-associated gene silencing may also suppress somatic expansions that contribute to disease progression
allergy  
HDAC3 serves as a target for development of allergy therapeutics.
ANIMAL & CELL MODELS
  • deletion of Hdac3 or Nr1d1 in mouse liver causes hepatic steatosis