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FLASH GENE
Symbol AKT2 contributors: mct/npt/pgu - updated : 24-08-2017
HGNC name v-akt murine thymoma viral oncogene homolog 2
HGNC id 392
ASSOCIATED DISORDERS
corresponding disease(s) NIDDM6
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in ovarian carcinoma
tumoral   amplification    
in ovarian and pancreatic carcinomas
tumoral somatic mutation      
in the kinase domain occuring in a small fraction of common cancers
tumoral       gain of function
associated with the survival of melanoma cells
tumoral   amplification    
amplification of AKT1 and/or AKT2 and high-level polysomy were found in lung carcinomas
tumoral fusion      
recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerbrainglioma/neuroblstoma
targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas
cardiovascularatheromacardiac
argeting AKT2 in macrophages might be beneficial for treating atherosclerosis.
ANIMAL & CELL MODELS
  • Akt2-deficient mice showed abnormal elastic fibers and reduced medial thickness in the aortic wall