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FLASH GENE
Symbol GPC4 contributors: mct - updated : 25-05-2016
HGNC name glypican 4
HGNC id 4452
ASSOCIATED DISORDERS
corresponding disease(s) SGBS , NDAS
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Gpc4-deficient mice have defective synapse formation, with decreased amplitude of excitatory synaptic currents in the developing hippocampus and reduced recruitment of AMPARs to synapses
  • Gpc4 KO mice display morphological abnormalities reminiscent of Keipert syndrome: they have significantly shorter paw and snout lengths than WT mice