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FLASH GENE
Symbol ITPKA contributors: mct - updated : 16-04-2014
HGNC name inositol 1,4,5-trisphosphate 3-kinase A
HGNC id 6178
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --other  
ectopic expression in lung cancer cells increases their metastatic potential because the protein exhibits two actin regulating activities
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerlung 
inhibitors against the actin bundling activity of ITPKA to effectively inhibit the stimulating effect of ITPKA on metastasis of lung cancer
cancerlung 
may be a promising therapeutic molecular target for anti metastatic therapy of lung cancer
cancermetastases 
potential targets of anti-metastatic therapy
ANIMAL & CELL MODELS