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FLASH GENE

Symbol

ITPKA

contributors: mct - updated : 16-04-2014

HGNC name	inositol 1,4,5-trisphosphate 3-kinase A
HGNC id	6178

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   ectopic expression in lung cancer cells increases their metastatic potential because the protein exhibits two actin regulating activities

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   inhibitors against the actin bundling activity of ITPKA to effectively inhibit the stimulating effect of ITPKA on metastasis of lung cancer cancer lung   may be a promising therapeutic molecular target for anti metastatic therapy of lung cancer cancer metastases   potential targets of anti-metastatic therapy

ANIMAL & CELL MODELS