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FLASH GENE
Symbol ABI1 contributors: mct/ - updated : 23-08-2011
HGNC name abl-interactor 1
HGNC id 11320
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker useful diagnostic or prognostic molecular biomarker in gastric carcinoma
Therapy target
SystemTypeDisorderPubmed
cancerdigestivestomach
a potential target for therapeutic intervention
cancerreproductivebreast
therapeutic target for the treatment of human breast cancer
cancermetastases 
development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for the treatment of metastatic tumors
immunologyinflammatory 
development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for inflammatory immune disorders
ANIMAL & CELL MODELS
  • embryonic lethality of Abi1-deficient embryos, which survived until approximately embryonic day 11.5 and displayed malformations in the developing heart and brain