Symbol
| ABI1
| contributors: mct/ - updated : 23-08-2011
|
HGNC name
| abl-interactor 1
|
HGNC id
| 11320
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --low
|  
|
in gastric carcinoma may play a critical role in tumor progression and in determining patient prognosis | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| useful diagnostic or prognostic molecular biomarker in gastric carcinoma | Therapy target
|
System | Type | Disorder | Pubmed |
cancer | digestive | stomach | |
a potential target for therapeutic intervention | cancer | reproductive | breast | |
therapeutic target for the treatment of human breast cancer | cancer | metastases | | |
development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for the treatment of metastatic tumors | immunology | inflammatory | | |
development of inhibitors of the ABI1–ITGA4 interaction may be an alternative therapeutic strategy for inflammatory immune disorders |
| | |
| embryonic lethality of Abi1-deficient embryos, which survived until approximately embryonic day 11.5 and displayed malformations in the developing heart and brain | |
|