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FLASH GENE
Symbol PLA2G6 contributors: mct - updated : 15-02-2012
HGNC name phospholipase A2, group VI (cytosolic, calcium-independent)
HGNC id 9039
ASSOCIATED DISORDERS
corresponding disease(s) NBIA2 , INAD1 , PARK14
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
results in excessive exocytosis through increased oxidative damage (or failure to repair such damage) and defects in mitochondrial function (
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neuromuscularmyopathy 
inhibition of iPLA(2) and lysophospholipid production may be of interest to reduce Ca(2+) entry and subsequent degeneration of dystrophic muscle
ANIMAL & CELL MODELS