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FLASH GENE
Symbol EIF6 contributors: mct - updated : 01-02-2015
HGNC name eukaryotic translation initiation factor 6
HGNC id 6159
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colorectal tumor (transition from benign to malignant tumor)
tumoral     --over  
in head and neck carcinomas and their lymph node metastases
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
Modulation of eIF6 activity, independent from EIF4F complex, may lead to a therapeutical avenue in tumor therapy
ANIMAL & CELL MODELS
  • eIF6(+/-) mice resist to Myc-induced lymphomagenesis and have prolonged tumor-free survival and reduced tumor growth, and are also protected by Tp53 loss