Symbol
| EIF6
| contributors: mct - updated : 01-02-2015
|
HGNC name
| eukaryotic translation initiation factor 6
|
HGNC id
| 6159
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in colorectal tumor (transition from benign to malignant tumor) | tumoral
|  
|  
| --over
|  
|
in head and neck carcinomas and their lymph node metastases | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
Modulation of eIF6 activity, independent from EIF4F complex, may lead to a therapeutical avenue in tumor therapy |
| | | |
| eIF6(+/-) mice resist to Myc-induced lymphomagenesis and have prolonged tumor-free survival and reduced tumor growth, and are also protected by Tp53 loss |