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FLASH GENE
Symbol ATF4 contributors: mct/shn - updated : 21-09-2019
HGNC name activating transcription factor 4 (tax-responsive enhancer element B67)
HGNC id 786
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in gastric cancer
constitutional     --over  
increased ATF4 expression is both necessary for upregulation of DDIT4 expression in response to ER stress and sufficient to upregulate expression of the protein
constitutional     --low  
loss of ATF4 delays skeletal muscle atrophy induced by fasting or immobilization
constitutional     --low  
resulted in enhanced oxidative damage, and increased free cholesterol in liver under stress accompanied by lowered cholesterol in sera
Susceptibility to schizophrenia in male patients
Variant & Polymorphism SNP increasing the risk of schizophrenia in male patients
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
abrogation of ATF4 expression significantly inhibited tumour growth
cancer  
ATF4 antagonists would be worth investigating for anti-tumour effects
cancer  
ATF4 and HMOX1 are potential targets for therapeutic intervention in solid tumors
obesity  
ATF4/ATG5 axis in the hypothalamus may be a new potential therapeutic target for treating obesity and obesity-related metabolic diseases
digestiveliver 
may be considered a therapeutic target for non-alcoholic fatty liver disease (NAFLD)
ANIMAL & CELL MODELS
  • Atf4 knockout mice exhibit severe microphthalmia
  • ATF4-deficient mouse neurons exhibit markedly reduced levels of PUMA expression and cell death (