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FLASH GENE
Symbol CUL4B contributors: mct - updated : 09-10-2017
HGNC name cullin 4B
HGNC id 2555
ASSOCIATED DISORDERS
corresponding disease(s) MRXSC
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
led to upregulation of PPARG-regulated genes and facilitated adipogenesis
tumoral        
can effectively inhibit osteosarcoma cell proliferation and induce apoptosis
tumoral     --over  
high mRNA expression of CUL2, CUL4B, and CUL5 were correlated with better survival for breast cancers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • can be served as a novel independent prognostic marker for the prediction of recurrence in colon cancer
  • Therapy target
    SystemTypeDisorderPubmed
    obesity  
    could be a potential therapeutic target for combating obesity and metabolic syndromes
    cancerbone 
    biomarker for the treatment of osteosarcoma
    cancer  
    target for cancer therapy
    ANIMAL & CELL MODELS
  • RNA interference silencing of CUL4B led to an inhibition of cell proliferation and a prolonged S phase, due to the overaccumulation of cyclin E (
  • Knocking down CUL4B increases WDR5 and trimethylated H3K4 on the neuronal gene promoters and induces their expression (
  • CUL4B depletion suppresses neurite outgrowth of PC12 neuroendocrine cells (
  • Cul4b null mouse embryos show severe developmental arrest and usually die before embryonic day 9.5 (E9.5)