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FLASH GENE
Symbol ADAMTS4 contributors: mct - updated : 18-09-2015
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 4
HGNC id 220
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
required to inhibit aggrecan degradation in human OA cartilage
tumoral     --over  
in Ewing sarcoma
constitutional     --over  
in acute coronary syndrome
constitutional     --low  
in the maternal and cord blood were lower in the preeclampsia group than in the control group
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is potentially a novel tumor marker for Ewing sarcoma
  • its expression may be a valuable marker for predicting the severity of acute coronary syndrome
  • Therapy target
    ANIMAL & CELL MODELS