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FLASH GENE
Symbol RNF40 contributors: mct - updated : 18-10-2012
HGNC name ring finger protein 40
HGNC id 16867
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
deficiency in histone H2B ubiquitin ligase RNF20/RNF40) leads to replication stress and chromosomal instability
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • deficiency in murine Rnf20/Rnf40 function associated with increased sensitivity to crosslinking drugs and defective formation of Rad51 foci in mouse cells, suggesting a defect in homologous recombinational repair analogous to that seen in Saccharomyces