Symbol
| RNF40
| contributors: mct - updated : 18-10-2012
|
HGNC name
| ring finger protein 40
|
HGNC id
| 16867
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| loss of function
|
deficiency in histone H2B ubiquitin ligase RNF20/RNF40) leads to replication stress and chromosomal instability | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| deficiency in murine Rnf20/Rnf40 function associated with increased sensitivity to crosslinking drugs and defective formation of Rad51 foci in mouse cells, suggesting a defect in homologous recombinational repair analogous to that seen in Saccharomyces | |
|