Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF8 contributors: mct/ - updated : 20-12-2019
HGNC name ring finger protein 8
HGNC id 10071
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility to autism spectrum disorder
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
could be used as a potential therapeutic target for the prevention and treatment of breast cancer
ANIMAL & CELL MODELS
  • Rnf8-deficient mice are viable but have multiple phenotypes including a growth retardation phenotype, increased sensitivity to IR, and impaired spermatogenesis
  • RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis
  • loss of Rnf8 or Rad6b can lead to sterility in male mice