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FLASH GENE
Symbol KIF11 contributors: mlc/npt/pgu - updated : 04-05-2020
HGNC name kinesin family member 11
HGNC id 6388
ASSOCIATED DISORDERS
corresponding disease(s) MLCD2 , EVR8
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast cancer correlated with worse outcomes
Susceptibility to type 2 diabetes
Variant & Polymorphism other polymorphism increasing the risk of type 2 diabetes
Candidate gene
Marker
  • potential prognostic biomarker in breast cancer
  • KIF11 expression might be indicative of prostate cancer (Pca) aggressiveness and could be useful as a prognostic marker for patients with PCa
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    KIF11 inhibitors, when able to permeate the blood-brain-barrier, could represent an interesting class of anticancer drugs with low neurotoxic effects in the treatment of brain tumors
    ANIMAL & CELL MODELS
  • in mice, Kif11 function in early postnatal CNS ECs is most significant in the two CNS regions-the retina and cerebellum-that exhibit the most rapid rate of postnatal growth, which may sensitize endothelial cells (ECs) to impaired mitotic spindle function