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FLASH GENE
Symbol KAT6B contributors: mct - updated : 10-02-2015
HGNC name K(lysine) acetyltransferase 6B
HGNC id 17582
ASSOCIATED DISORDERS
corresponding disease(s) OHDO , GPATS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fusion with CREBBP in acute myeloid leukemia with t(10;16) (q22;p13)
tumoral fusion      
in leiomyomata with chromosomal rearrangements involving 10q22 and 17q21 suggesting a role for this histone acetyltransferase and altered chromatin regulation in uterine mesenchymal neoplasia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Qkf-deficient mice have fewer neural stem cells and fewer migrating neuroblasts in the rostral migratory stream
  • mice carrying a hypomorphic mutation of Myst4 have short stature, an absence of fusion of the tibia and fibula, microcephaly with neurogenesis defects, early demise, and infertility