Symbol
| KAT6B
| contributors: mct - updated : 10-02-2015
|
HGNC name
| K(lysine) acetyltransferase 6B
|
HGNC id
| 17582
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
| fusion
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fusion with CREBBP in acute myeloid leukemia with t(10;16) (q22;p13) | tumoral
| fusion
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in leiomyomata with chromosomal rearrangements involving 10q22 and 17q21 suggesting a role for this histone acetyltransferase and altered chromatin regulation in uterine mesenchymal neoplasia | |
Candidate gene
Marker
Therapy target
| | | |
| Qkf-deficient mice have fewer neural stem cells and fewer migrating neuroblasts in the rostral migratory stream | |
mice carrying a hypomorphic mutation of Myst4 have short stature, an absence of fusion of the tibia and fibula, microcephaly with neurogenesis defects, early demise, and infertility |