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FLASH GENE
Symbol DDIT3 contributors: npt/shn - updated : 08-06-2015
HGNC name DNA-damage-inducible transcript 3
HGNC id 2726
ASSOCIATED DISORDERS
corresponding disease(s) DDIT3
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   translocation    
translocated with FUS in t(12;16)(q13;p11) and with ESWR1 in t(12;22)(q13;q12) in myxoid liposarcoma
constitutional       loss of function
in conjunction with a COMP mutation, may lead to aggravation of the skeletal phenotype via a potentially synergistic effect on endochondral ossification
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabete  
therapeutic potential of CHOP inhibition in the management of diabetic cardiovascular complications including diabetic cardiomyopathy
digestiveliver 
targeting DDIT3/ERO1A signalling could be a novel therapeutic approach during acute liver failure (ALF)
ANIMAL & CELL MODELS
  • Chop-null mice are resistant to fibrosis, which is a key risk factor for hepatocellular carcinoma (HCC)