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FLASH GENE
Symbol GSTP1 contributors: mct/npt/pgu/shn - updated : 03-10-2014
HGNC name glutathione S-transferase pi 1
HGNC id 4638
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
in prostate cancer by methylation of promoter
constitutional     --low  
in placentas of preeclampsia and HELLP syndrome
tumoral     --low  
in tissues of esophageal carcinomas compared to adjacent normal tissues and residual benign tissues
Susceptibility
  • susceptibility factor in squamous-cell carcinoma of the esophagus and in Barrett's esophagus carcinoma
  • to chronic obstructive pulmonary disease
  • to lung cancer
  • to childhood asthma
  • to type-2 diabetes
  • Variant & Polymorphism SNP
  • increasing the risk of chronic obstructive pulmonary disease
  • chemotherapy induced leukemia
  • Ile105Val polymorphism in the GSTP1 gene and childhood asthma is significantly associated in childhood asthma, modified by GSTM1
  • GSTP1 exon 5 polymorphism, associated with risk of lung cancer in smokers
  • Candidate gene
  • for sensitive detection in plasma or serum of cancer gastric and prostatic, using DNA methylation markers
  • for macular telangiectasia type 2
  • methylation of the promoter is a common molecular alteration in prostate cancer that may be a useful adjunct to serum screening tests and digital rectal examination findings
  • Marker
  • strong associations between APC, GSTP1 and SOCS1 gene promoter methylation and the risk of HCC, suggesting these to be promising biomarkers for hepatocellular carcinoma (HCC)
  • Therapy target
  • intraperitoneally administation of GSTP1 in mouse models of endotoxin shock significantly decreased mortality of endotoxic shock and inhibited acute lung injury and peritonitis
  • ANIMAL & CELL MODELS