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FLASH GENE
Symbol ZNF217 contributors: mct - updated : 20-06-2017
HGNC name zinc finger protein 217
HGNC id 13009
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification --over  
in breast carcinoma with poor prognosis
tumoral   amplification    
in ovarian cancer
tumoral        
silencing of ZNF217 resulted in the effective inhibition of ovarian cancer cell growth and invasive ability
tumoral     --over  
in primary breast tumours had a higher risk of developing bone metastases
tumoral     --over  
promotes prostate cancer growth by restraining SLC40A1-conducted iron egress
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • is a crucial mediator and indicator of bone metastasis
  • ZNF217 mRNA expression may represent a novel prognostic biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    future therapies targeting ZNF217 and/or the BMP signalling pathway may be beneficial by preventing the development of bone metastases
    ANIMAL & CELL MODELS