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FLASH GENE
Symbol LOXL2 contributors: mct - updated : 27-04-2015
HGNC name lysyl oxidase-like 2
HGNC id 6666
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in metastatic breast cancer-derived cell lines
tumoral     --over  
in colon and esophageal cancer and may contribute to tumor progression
tumoral     --over  
is a frequent event in gastric carcinoma progression (
tumoral       gain of function
one of the most highly and specifically upregulated genes in pancreatic cancer
tumoral     --over  
correlated with decreased overall survival and metastasis-free survival in breast cancer patients with ERBB2-positive tumors
Susceptibility to intracranial aneurysm
Variant & Polymorphism SNP SNP7 showed an empirically significant association with intracranial aneurysm
Candidate gene
Marker
  • may be a beneficial marker for breast cancer patients that could benefit most from anti-ERBB2 therapy
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    development of anti-LOXL2 therapeutics for the treatment of metastatic breast cancer
    cancerdigestivestomach
    may be a therapeutic target for preventing and treating metastases
    cancer  
    antibody allosteric modulators of enzymatic function represent a novel useful therapeutics in oncology
    immunologyinflammatory 
    antibody allosteric modulators of enzymatic function represent a novel useful therapeutics in inflammation
    cancerdigestivepancreas
    improved response toward chemotherapy in LOXL2-silenced pancreatic cancer cells is possibly mediated by the transcription factor E2F5
    cancerskin 
    target for squamous cell carcinoma progression therapy
    ANIMAL & CELL MODELS
  • germ-line deletion of Loxl2 promotes lethality in half of newborn mice mainly associated to congenital heart defects, while Loxl2 overexpression triggers male sterility due to epididymal dysfunction caused by epithelial disorganization, fibrosis and acute inflammation